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pentobarbital will minimize the extent or result of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of abemaciclib with powerful CYP3A4 inducers cuts down plasma concentration of abemaciclib and its metabolites.Warning when discontinuing CYP3A4 inducers which are coadminis